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    irreversible

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    irreversible
    ir‧re‧ver‧si‧ble AC /ˌɪrɪˈvɜːsəbəl◂, ˌɪrɪˈvɜːsɪbəl◂ $ -ɜːr-/ adjective
     Word Family: noun: reversal, reverse; adjective: reverse, reversible ≠ irreversible; verb: reverse
    1. irreversible damage, change etc is so serious or so great that you cannot change something back to how it was before
       OPP  reversible:
        Fossil fuels have caused irreversible damage to the environment
    2. if an illness or bad physical condition is irreversible, it will continue to exist and cannot be cured:
        Miller is in an irreversible coma.
        irreversible blindness
    —irreversibly adverb:
        His reputation was irreversibly damaged by the affair.